鞘磷脂Analysis Service

Spingomyelin（SM）是生物膜组成中的重要组成部分之一。随着对动物中SM的深入研究和酵母，SM及其代谢物，如神经酰胺（CER），鞘氨醇（SPH）和鞘氨磷酸鞘磷酸盐（鞘氨醇 - 磷酸，S1P）是一类重要的生物活性信号分子，这参与了细胞生长，分化，衰老和死亡以及许多其他重要信号转导过程的调节。SM及其代谢物在各种疾病中起着关键作用，它们可以调节疾病发展中的多种环节。

创意蛋白质组学已经开发出一种可靠且可重复的方法，可使用高度敏感的LC-MS / MS方法来快速识别和量化鞘磷脂和其代谢物，这可以满足您实验室学术和工业研究的需求。

Sphingomyelin is not only an important part of cell membranes, but also a dietary ingredient. It is most abundant in foods such as eggs, meat, fish and milk. Sphingomyelin has a potential inhibitory effect on colon cancer. In addition, sphingomyelin has the effects of lowering serum cholesterol, improving skin barrier function and promoting neurodevelopment of infants and young children. These studies make sphingomyelin a potential functional food. We can also analyze the composition of sphingomyelin in food, which is helpful for food safety and quality control.

Our Sphingomyelin Analysis Service

绝对量化：使用外部标准方法量化，并使用内部标准进行校正，定性和定量更准确。

High sensitivity: We use liquid chromatography coupled with triple quadrupole mass spectrometers for sphingomyelin analysis service (Triple Quad™ 6500 LC-MS/MS System).

Fig 2. The workflow of sphingomyelin analysis service

Sample Requirements

Why Choose Us?

• 通过集成的分离，表征，识别和定量系统，具有出色的鲁棒性和再现性，高和超灵敏度，创意蛋白质组学提供可靠，快速且具有成本效益的SM分析服务。
• 定制的提取协议和拓展方法，以针对客户的不同需求。
• Creative Proteomics full-service facility provides data processing (e.g., data alignment, feature detection), feature prioritization (e.g., principal component analysis, heat maps, ANOVA/t-test, multivariate statistical analysis, self organizing maps, volcano plots, and network activity prediction), and lipid identification services.

If you have any questions about our SM analysis services, pleasecontact us.

References:

1. Slotte J P. Biological functions of sphingomyelins.脂质研究进展. 2013, 52(4): 424-437.
2. Barenholz Y。双层和生物膜中的鞘氨胺蛋白。Biochimica et Biophysica Acta (BBA)-Biomembranes. 1980, 604(2): 129-158.

Related Sections:

• Sterol Lipids Analysis Service
• Fatty Acyls Analysis Service
• Glycerophospholipids Analysis Service
• Glycerolipids Analysis Service
• Sphingolipids Analysis Service
• Untargeted Lipidomics
• 有针对性的脂多元族学
• 脂质虫生物信息分析
• Lipidomics Service