Cardiovascular Disease Metabolomics Service

大多数心血管疾病的心脏代谢疾病是基于大多数心血管疾病的基础。代谢组学是揭示心血管疾病状态中总体和特定地区代谢变化的强大工具。代谢组学分析可以揭示心血管疾病（CVD）病因的代谢异常，从而有助于鉴定新型的生物标志物。

The human heart beats an average of 2.5-4 billion times in a lifetime, yet despite breaking down 20 times its weight in ATP per day, it can store only enough energy to sustain a few heartbeats. Therefore, the heart must adapt to changing nutritional availability and physiological demands to meet ongoing energy needs. In fact, the heart can produce ATP from a variety of sources including carbohydrates, lipids, lactic acid, amino acids and ketone bodies. Most cardiovascular diseases involve cardiometabolic disorders due to the critical need for a continuous energy supply.

此外，糖尿病等疾病中的代谢紊乱直接影响心脏代谢。心脏病本身也会影响全身代谢。因此，全身和心脏代谢疾病可能会引发恶性循环，导致心血管疾病。

创意蛋白质组学为心血管疾病提供了代谢组分析解决方案，将靶向和未靶向的代谢组学技术与多变量分析相结合，以探索疾病机制，筛查生物标志物，并促进药物发育以及疾病的诊断和治疗。

心血管疾病代谢组分析的策略

有两种主要方法可以使用代谢组学识别和分析代谢物：未靶向的代谢组学和靶向代谢组学。

未靶向的代谢组学用于评估样品中的代谢物，可以揭示代谢物的新变化或意外变化。它的主要优点是它提供了一种公正的方法来分析来自多个途径的相互关联代谢物之间的关系。可以详细评估样品中的代谢物，揭示各种代谢物类别。

Targeted metabolomics measures the concentrations of a predefined set of metabolites. A standard curve for the concentration range of the target metabolite is prepared, resulting in accurate quantification. This type of analysis can be used to obtain the concentration of an exact metabolite determined by untargeted metabolomics, thus providing analytical validation. Targeted metabolomics offers higher sensitivity and selectivity than non-targeted metabolomics.

心血管疾病的代谢组学分析过程

Technology Platform for Metabolomics Analysis

多个分析平台，包括GC-MS，LC-MS，UPLC-MS。可以从单个生物样品中筛选成千上万的代谢产物，从而为探索疾病机制提供了全面的方法。

Creative Proteomics是生物制药研究的良好合作伙伴，在代谢组学分析方面拥有丰富的经验。我们为代谢组学分析方向提供心血管疾病研究的解决方案，从而加速了科学新视野的探索。如果您想了解更多，请contact us. Looking forward to cooperating with you.