Metabolomics and Veterinary and Animal Health

作为生物学的重要组成部分，代谢组学对许多生物学领域产生了深远的影响。代谢组学技术平台are playing an increasingly important role in the fields of health and disease, nutritional sciences, agriculture, plants, microbiology, medicine, resources and environment. The study of animal diseases and animal pharmacology is a major component of veterinary medicine. Metabolomic technologies play an important role in the diagnosis of animal diseases and in ensuring high quality veterinary drugs.

Fig 1. Untargeted metabolomics profiling (Zeki,等。，2020年）

Application of metabolomics in veterinary drug development

Metabolomics is used throughout the process of early discovery to clinical development of new drugs. The monitoring of metabolite changes can be used to observe the physiological status of animal models without harm and to dynamically evaluate drug-organism interactions. At present, metabolomics has been applied to drug screening, drug efficacy and toxicity evaluation, drug mechanism of action, etc.

While a healthy organism is in dynamic equilibrium, the development and progression of disease is accompanied by an imbalance in this homeostasis. Successful drugs must normalize the defective parts of the metabolic network without interfering with other metabolic pathways necessary to maintain health. The discovery and development of new drugs is about adjusting metabolic pathways through the metabolic network to restore them from a disease state to a normal state without disturbing the balance of other metabolisms and reducing and eliminating adverse effects or toxicity. The above holistic concept of metabolomics is also applicable in the development of veterinary drugs. It has great application in the study of mechanism of action of veterinary drugs, pharmacokinetics, drug metabolism, pharmacodynamics of animal disease models and clinical trials.

代谢组学用于对动物药物的质量检查，以分析不同药物对动物病例治疗的效果分析。例如，甲硝唑主要用于治疗鸡在鸡中的毛诺病等。代谢组学技术的应用可用于分析通过质谱法中甲硝唑残基在鸡的代谢中的含量，并比较病毒细胞在病毒细胞中的数量用于全面分析的代谢组，从而达到了动物药物质量检查的作用。

Application of metabolomics in disease diagnosis

Changes in internal and external environmental factors may produce pathogenic factors, which may lead to disruption of body homeostasis and consequently pathological processes, and corresponding changes in the metabolites of the body. Metabolomic analysis of the metabolite response can be used to understand the root cause of disease development and to propose more optimal disease solutions. The analysis of metabolic networks allows the identification of disease-related biomarkers that can contribute to the clinical diagnosis of diseases. The application of metabolomics in disease research is mainly reflected in the discovery of lesion markers, animal disease model research, diagnosis, treatment and prognosis of diseases, etc.

With the development of scale and intensification of farming, malignant infectious diseases have been effectively controlled. However, the incidence of diseases caused by a combination of factors is increasing, and the etiology is difficult to solve. These include dairy cattle hoof fever, osteochondrosis, and nutritional metabolic diseases. Metabolomics, in combination with other histological techniques, can be used to explore the etiology of diseases at the molecular level and make disease treatment more targeted.

Reference

1. Zeki，Ö。C.，Eylem，C.C.，Reçber，T.，Kır，S。，＆Nemutlu，E。（2020）。GC-MS和LC-MS的整合，用于非靶向代谢组学分析。《药物与生物医学分析杂志》，113509。

Related Sections

Animal Metabolomics Service

血浆和血清代谢组学

Urine Metabolomics