生物膜是特殊的膜组织,微生物用来在外部压力条件下维持其生存。生物膜通常被细胞外聚合物(EPS)基质包围,该基质赋予细菌耐药性,对杀菌剂,抗生素和其他侵袭。在临床实践中,生物膜形成直接导致超过90%的抗生素耐药性的发展。它同样与肿瘤,糖尿病和神经系统疾病中耐药性(由于细菌感染引起的病变形成生物膜形成)的发展有关。此外,生物膜的形成对多个行业构成了重大风险,例如金属精密仪器的腐蚀,水环境污染,食物污染,ETC。It is necessary to explore the research on microbial biofilms and analyze the molecular mechanism of their formation.
Creative Proteomics provides biofilm metabolomics solutions for industrial and academic customers. Based on targeted metabolomics and untargeted metabolomics strategies, we combine other technologies to analyze the functional metabolites that regulate biofilm formation from the perspective of small molecule metabolism and explore the metabolic mechanism of biofilm formation. We provide data to support the removal of biofilm formation in different fields and inhibit its toxic and harmful effects.