Amino Acids and Derivatives Analysis ServiceOnline Inquiry

Amino acids are organic compounds containing basic amino and acidic carboxyl groups, which are the basic units of enzymes and proteins. As small biological molecules, amino acids play an important role in physiological functions and clinical diagnosis. In general, amino acids play the following roles in the body: (1) synthesize tissue proteins; (2) turn into ammonia-containing substances such as acids, hormones, antibodies, and creatine; (3) transform into carbohydrates and fats; and (4) oxidize into carbon dioxide and water and urea to produce energy.

There are 20 common amino acids according to the structure on the side chain R group. According to nutritional classification, it is divided into essential amino acids, semi-essential amino acids and conditionally essential amino acids. In addition, there are nearly a hundred kinds of derivatives of amino acids. Different amino acids and their derivatives have different nutritional values and physiological functions, and play different roles in the body. If the body is deficient in any one amino acid, it may lead to abnormal physiological functions,affect the normal progress of metabolism and finally lead to diseases. Arginine and citrulline are important for urea formation; insufficient intake of cystine can cause decreased insulin and increased blood sugar, etc. The presence of amino acids not only provides important raw materials for protein synthesis, but also provides the material basis for promoting growth, carrying out normal metabolism and maintaining life. If one of them is missing, the normal metabolism of the organism will be impaired, even leading to the occurrence of various diseases or the termination of life activities.

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After years of technical accumulation, Creative Proteomics has combined GC/MS and LC/MS/MS to achieve quantitative and qualitative analysis of more than 100 amino acids and their derivatives, including 8 essential amino acids and 2 semi-essential amino acids and conditionally essential amino acids, 10 non-essential amino acids, and other amino acids.

Quantitative Amino Acids List
No	Metabolite	No	Metabolite	No	Metabolite	No	Metabolite
1	Glycine	30	L-Homoserine	59	Creatine	88	N-Acetylalanine
2	L-Alanine	31	L-Thyronine	60	Cysteinylglycine	89	N-Acetylaspartic acid
3	L-Arginine	32	1-Methyl-L-histidine	61	Guanidoacetic acid	90	N-Acetylcysteine
4	L-Asparagine	33	3-Methyl-L-histidine	62	Homocitrulline	91	N-Acetylglutamic acid
5	L-Aspartic acid	34	2-aminobutyric acid	63	Homoarginine	92	N-Acetylglutamine
6	L-Cysteine	35	2-Aminoisobutyric acid	64	Argininosuccinic acid	93	N-Acetylhistidine
7	L-Cystine	36	3-Aminobutyric acid	65	Glycylproline	94	N-Acetylisoleucine
8	L-Glutamic acid	37	3-Aminoisobutyric acid	66	Glycyl-L-leucine	95	N-Acetylleucine
9	L-Glutamine	38	Gamma-Aminobutyric acid	67	Carnosine	96	N-Acetylmethionine
10	L-Histidine	39	2,3-Diaminopropionic acid	68	Anserine	97	N-Acetylphenylalanine
11	L-Isoleucine	40	2-Aminoadipic acid	69	Cystathionine	98	N-Acetylproline
12	L-Leucine	41	3-Chlorotyrosine	70	Glycyl-glycine	99	N-Acetyltryptophan
13	L-Lysine	42	2-Phenylglycine	71	O-Acetylserine	100	N-Acetyltyrosine
14	L-Methionine	43	3-Methylcrotonylglycine	72	Phenylacetylglutamine	101	N-Acetylvaline
15	L-Ornithine	44	3-Nitrotyrosine	73	Phenylacetylglycine	102	N-Acetyllysine
16	L-Phenylalanine	45	4-Acetamidobutyric acid	74	Phosphoserine	103	N-Acetylcitrulline
17	L-Proline	46	4-Amino-3-hydroxybutyric acid	75	S-Adenosylhomocysteine	104	N6-Acetyllysine
18	L-Serine	47	4-Hydroxyphenylglycine	76	S-Adenosylmethionine	105	Ureidopropionic acid
19	L-Threonine	48	4-Hydroxyproline	77	Sarcosine	106	Ureidosuccinic acid
20	L-Tryptophan	49	5-Aminolevulinic acid	78	S-Carboxymethylcysteine	107	Cinnamoylglycine
21	L-Tyrosine	50	5-Aminopentanoic acid	79	Methylcysteine	108	Formylglycine
22	L-Valine	51	5-Hydroxytryptophan	80	gamma-Glutamylalanine	109	我sobutyrylglycine
23	L-Norleucine	52	5-Hydroxylysine	81	gamma-Glutamylglutamine	110	我sovalerylglycine
24	L-Norvaline	53	6-Aminocaproic acid	82	N-Acetylaspartylglutamic acid	111	N-Phenylacetylphenylalanine
25	L-Pipecolic acid	54	Asymmetric dimethylarginine	83	Phenylalanylphenylalanine	112	Tiglylglycine
26	L-Kynurenine	55	Symmetric dimethylarginine	84	Dimethylglycine	113	Valylglycine
27	L-Allo-isoleucine	56	Beta-Alanine	85	N-Acetylarginine	114	3-Iodo-L-tyrosine
28	L-Homocysteine	57	Pyroglutamic acid	86	N2-Acetylornithine	115	3,5-Diiodo-L-tyrosine
29	L-Homocystine	58	Citrulline	87	Acetylglycine	116	Thyroxine

Amino Acids and Derivatives Analysis Workflow

Sample Requirements

Animal and clinical tissue samples: > 5-10mg

Blood samples (serum, plasma and whole blood):>10uL

Urine sample:>10uL

Fecal and intestinal contents:>10mg

Body fluid samples (cerebrospinal fluid and saliva, etc.): >5-10μL

Plant tissue samples (roots, stems, leaves flowers and fruits, etc.): >10mg

Cells and microorganisms:>1*10^5cells

Culture medium and fermentation broth:>10μL

Platform

Agilent UHPLC-MS/MS

Waters UPLC-AB Sciex MS/MS

Thermo Scientific Orbitrap MS

Agilent GC-MS

Applications

Phenome and physiological function studies.

Early clinical prediction, diagnosis and treatment studies.

Pathology studies.

Natural drugs and pharmacological research.

Food science, safety and nutrition research.

Livestock and agroforestry research.

Botanical and environmental research.

Toxicological research.

* For Research Use Only. Not for use in diagnostic procedures.

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